Prolonged use of antidepressant medication is associated with a significantly increased risk of sudden cardiac death (SCD), according to new research presented at the European Heart Rhythm Association’s annual conference, held from March 30 to April 1.
The study, led by Dr. Jasmin Mujkanovic of Rigshospitalet Hjertecentret in Copenhagen, Denmark, examined the link between antidepressant exposure and SCD in the Danish adult population in 2010. Researchers analyzed data from death certificates and autopsy reports, identifying 6,002 cases of sudden cardiac death among 45,701 total deaths.
Among nearly 644,000 adults who had used antidepressants in the year prior, 1,981 cases of SCD were recorded. The incidence of sudden cardiac death was significantly higher in this group compared to the general population.
After adjusting for age, sex, and existing medical conditions, the researchers found that individuals with one to five years of antidepressant exposure faced a 56% higher risk of SCD. Those with six or more years of use had more than double the risk.
The risk varied by age group. Adults aged 30 to 39 with one to five years of antidepressant use were nearly three times more likely to suffer sudden cardiac death. The risk was doubled for those aged 50 to 59, and individuals aged 70 to 79 faced an 83% increased risk.
“The increased risk of sudden cardiac death may be attributed to the potential adverse effects of the antidepressants,” Dr. Mujkanovic said in a statement. “However, the exposure time to antidepressants might also serve as a marker for more severe underlying illness.”
The findings highlight the need for closer monitoring of long-term antidepressant users and further research into the cardiovascular effects of psychiatric medications.
Related topics:
Study Links Body Fat to Anxiety, Offering New Treatment Insights
Mental Health Disorders Linked to Lower Parenthood Rates in Finland
The Mental Health Toll of Cyber-Sexual Harassment: A Growing Crisis
